Book of Genesis, the first book of the biblical scriptures of both Judaism and Christianity - describing the creation of the Earth and of mankind
Genesis creation narrative, the first several chapters of the Book of Genesis, which describes the origin of the Earth
Genesis Rabbah, a midrash probably written between 300 and 500 CE with some later additions, comprising a collection of interpretations of the Book of Genesis
Literature and comics
Genesis (DC Comics), a 1997 DC Comics crossover
Genesis (Marvel Comics), a Marvel Comics villain
Genesis, a fictional character from the Preacher comic-book series
Genesis, a 1951 story by H. Beam Piper
Genesis: The Origins of Man and the Universe, a 1982 science text by John Gribbin